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. Author manuscript; available in PMC: 2020 Sep 16.
Published in final edited form as: Nat Methods. 2020 Mar 16;17(5):524–530. doi: 10.1038/s41592-020-0793-0

Extended Data Fig. 6. Asymmetric effects of negative and positive net charges on intracellular diffusion.

Extended Data Fig. 6

(a) A negatively charged diffuser is readily neutralized by the abundant, small metal cations inside the cell, and so diffuses similarly as neutral counterparts. (b) A positively charged diffuser is not effectively neutralized/screened by the very limited amount of intracellular small anions; its dynamic interactions with the negatively charged, large biomolecules insides the cell substantially hinder diffusion.