Table 12.1.
List of some diseases associated with cullin-RING ligases
| CRL | Cellular function | Related diseases |
|---|---|---|
| CRL1β-TrCP1 | Cell adhesion and signaling | Gastric cancer; split hand-split foot malformation |
| CRL1Skp2 | Cell division | Lung cancer; squamous cell carcinoma |
| CRL1Atrogin1 | Muscle differentiation | Muscle wasting; dilated cardiomyopathy |
| CRL2LRR-1 | Cell migration | |
| CRL2VHL | Hypoxic response | von Hippel-Lindau disease; renal cell carcinomas |
| CRL3KLHL9 | Cytokinesis | Early onset distal myopathy |
| CRL3SPOP | Cell growth and development | |
| CRL3Keap1 | Oxidative stress response | Pulmonary papillary; adenocarcinoma |
| CRL4DDB2 | DNA damage response | Xeroderma pigmentosum; cockayne syndrome |
| CRL4Cdt2 | Cell division | |
| CRL5SOCS3 | Cytokine signaling | Diabetes |
| CRL5ASB3 | T-cell signaling regulation |