Table 1.
Mutations of evolved strains identified by genome sequencing.
| Gene ID | Gene name | Gene product | Nucleotide alteration | Amino acid alteration | Strain |
|---|---|---|---|---|---|
| cgl0111 | atlR | Multi-function regulator of carbohydrate metabolism | T437G | I146S | MX-10, MX-11, MX-12, MX-13, and MX-14 |
| cgl2030 | – | Predicted ATPase with chaperone activity | C535T | P179S | |
| cgl2192 | ctaE | Cytochrome c oxidase subunit III | A433G | T145A | |
| cgl2424 | – | Uncharacterized membrane protein | C446A | A149E | |
| cgl0653 | metY | O-Acetyl-l-homoserine sulfhydrylase | G1256A | G419D | MX-11, MX-12, MX-13, and MX-14 |
| cgl0754 | mtrA | Dual regulator of genes involved in cell morphology, antibiotics susceptibility and osmoprotection | C582A | H194Q | |
| cgl1367 | uriR | Transcriptional repressor of uridine utilization and ribose uptake genes | C584T | T195I | |
| cgl1520 | – | Hypothetical protein | A574G | M192V | |
| cgl2998 | – | Hypothetical protein | G104T | G35V | |
| cgl2365 | – | Hypothetical membrane protein | C542G | A181G | MX-12 |
| cgl2857 | – | Membrane protein required for lipomannan maturation and lipoarabinomannan synthesis | G183A | T61T | MX-13 |
| cgl0833 | mctC | Monocarboxylic acid transporter | C1439T | S480F | MX-14 |