Table 5.
Peak laboratory prognostic markers
| Laboratory valuesa | All (N=64) | Severe group (n=44) | Critical group (n=20) | P value |
|---|---|---|---|---|
| IL-6 (≤1.8 pg/mL)b | 70.4±68.1 | 40.0±27.6 | 93.2±81.8 | .008 |
| Ferritin (5–130 ng/mL) | 311.0±647.5 | 195.7±192.8 | 469.5±967.3 | .0003 |
| Disease day of peak | 13.0±6.1 | 11.1±4.3 | 15.2±7.4 | .007 |
| Fibrin split products (μg/mL) | 690.8±405.7 | 843.0±181.7 | 462.5±647.0 | .0006 |
| Disease day of peak | 11.1±4.3 | 8.7±1.2 | 18 | — |
| Liver enzymes (5–35 U/L) | ||||
| AST | 74.0±70.2 | 71.4±82.2 | 79.3±35.6 | .68 |
| ALT | 60.2±59.8 | 53.0±58.4 | 74.8±61.5 | .18 |
| Disease day of peak | 11.4±6.1 | 10.0±5.0 | 13.9±7.3 | .015 |
| Platelets (150–420 109/L) | 350.1±153.1 | 307.8±123.2 | 441.2±173.7 | .001 |
| Disease day of peak | 13.0±6.5 | 11.1±5.7 | 16.8±6.5 | .0007 |
| D-dimer (100–1500 ng/mL) | 1325.6±3388.5 | 745.5±979.5 | 2014.4±4893.1 | .101 |
| Disease day of peak | 13.3±6.8 | 12.3±7.6 | 14.5±6.0 | .26 |
| PT (10–13 s) | 12.9±1.4 | 12.3±0.9 | 13.8±1.6 | <.0001 |
| PTT (24–38 s)c | 37.1±20.0 | 31.6±3.4 | 44.8±29.5 | .004 |
| Disease day of peak | 11.2±6.1 | 9.0±5.0 | 13.7±6.4 | .002 |
| Procalcitonin (0.01–0.1 ng/mL) | 0.6±1.2 | 0.3±0.4 | 1.1±1.7 | .004 |
| Disease day of peak | 9.3±5.8 | 8.4±5.3 | 10.5±6.5 | .18 |
| Troponin (<0.04 mg/dL) | 0.7±3.0 | 0.01±0.01 | 1.5±4.5 | .03 |
| Disease day of peak | 12.0±7.5 | 10.4±4.6 | 13.1±9.1 | .12 |
| CRP (<20 mg/dL) | 83.7±82.0 | 43.3±45.9 | 141.9±88.6 | .0001 |
| Disease day of peak | 10.9±4.7 | 9.9±4.4 | 12.2±5.0 | .068 |
| CPK (13–101 U/L) | 280.4±286.5 | 92.8±83.7 | 485.1±290.9 | .0001 |
| Disease day of peak | 13.2±7.0 | 14.4±5.5 | 12.4±8.1 | .25 |
| LDH (80–450 U/L) | 364.9±164.3 | 317.0±157.6 | 467.6±131.2 | .0004 |
| Disease day of peak | 11.1±6.0 | 9.4±5.1 | 14.6±6.4 | .0009 |
Data are presented as (reference range value in pregnancy, unit) and mean day±standard deviation.
ALT, alanine aminotransferase; AST, aspartate aminotransferase; CPK, creatine phosphokinase; CRP, C-reactive protein; IL-6, interleukin-6; LDH, lactate dehydrogenase; PT, prothrombin time; PTT, partial thromboplastin time.
Pierce-Williams et al. Clinical course of severe and critical coronavirus disease 2019 in hospitalized pregnancies. AJOG MFM 2020.
a
Many of the reference ranges for these laboratory tests change by trimester
b
Reference range is for nonpregnant patients
c
Seventy-four percent of women received prophylactic or therapeutic anticoagulation, which will alter coagulation study results.