Table 2.

Cognition and senescence-related transcripts and isoforms used for expression analysis. Shown here are the transcripts and isoforms selected for analysis and a brief description of their function. Details of the type of AS event for each isoform, and the exons involved are provided in the references indicated

	Gene	Transcripts/isoforms	Function	References
Cognition-related transcripts	Aph1a	Aph1aL	Subunit of the gamma-secretase complex involved in β-amyloid processing	(Ma et al. 2005), (Serneels et al. 2005)
		Aph1aS
	App	App695	Precursor to β-amyloid protein	(Rohan de Silva et al. 1997), (Zhang et al. 2011)
		App714
		App751
		AppALL
	Aqp4	Aqp4-M1	Pore-forming intrinsic membrane protein	(De Bellis et al. 2014), (Jung et al. 1994), (Mader and Brimberg 2019)
		Aqp4-M23
	Gfap	Gfapα	Astrocyte intermediate filament protein	(Kamphuis et al. 2012)
		Gfapδ
	Mapt	Mapt-3R	Microtubule-associated protein tau involved in neurofibrillary tangles	(Goedert et al. 1989), (Lacovich et al. 2017)
		Mapt-4R
	Klotho	mKlotho	Endocrine factor which improves cognitive performance in ageing	(Masso et al. 2015)
		sKlotho
	Psen1	Psen1	Subunit of the gamma-secretase complex involved in β-amyloid processing	(De Jonghe et al. 1999), (Janssen et al. 2000)
		Psen1 (insTAC)
		Psen1 (VRSQ)
	Psen2	Psen2	Subunit of the gamma-secretase complex involved in β-amyloid processing	(Moussavi Nik et al. 2015), (Sato et al. 1999)
		Psen2 (Δexon5)
Senescence-related transcripts	Atm	Atm	DNA damage repair	(Marechal and Zou 2013)
	Cdkn1a	Cdkn1a (p21a)	Inhibitory to proliferation	(Kaija et al. 2012), (Nozell and Chen 2002)
	Cdkn2a	Cdkn2a (p14ARF)	p53 pathway to cell cycle arrest	(Tian et al. 2015), (Kim et al. 2011)
		Cdkn2a (p16INK4a)	RB1 pathway to cell cycle arrest
	Cdkn2b	Cdkn2b (p15INK4b)	TGFβ pathway to cell cycle arrest	(Tian et al. 2015)
	Tp53	Tp53	Cell cycle regulation	(Vousden and Lane 2007)