FIGURE 1.

The effect of prostaglandin analogues or beta‐blockers alone and in combination on the differential gene expression of fibrosis‐associated genes in trabecular meshwork tissue of primary glaucoma patients. Graphs indicate mean mRNA expression of TGFβ1, TGFβ2, TGFβR2, CTGF, FN, LOXL2, WNT3A, DECORIN and HEVIN normalized to expression of β‐ACTIN (housekeeping gene). The categories include TM from primary glaucoma patients using prostaglandin analogues (PG), beta‐blockers (BB) or combination of prostaglandin analogues and beta‐blockers (PG+BB). Panel A indicates gene expression profile in trabecular meshwork tissue of primary glaucoma patients (primary angle‐closure glaucoma—PACG and primary open‐angle glaucoma—POAG). Panel B indicates gene expression profile in trabecular meshwork tissue of PACG patients. Panel C indicates gene expression profile in trabecular meshwork tissue of POAG patients. Bar graphs represent the mean ± SEM of all patients. *P < .05, **P < .01, Mann–Whitney test