Figure 7.
CDK inhibitor sensitized TMZ in vivo. A, Nude mice were injected s.c. with 5 × 106 U87 cells. After 1 wk, mice were treated with TMZ, abemaciclib or their combination for 10 consecutive days. Tumour volume at indicated time‐points after treatment was calculated and plotted with P values, n = 6, in each group. B, Tumour weight was calculated at end of the experiments. C, The levels of indicated proteins in randomly selected tumours were analysed by Western blotting. D, Ki‐67 was analysed by IHC staining. E, Cleaved caspase 3 was analysed by IF staining