Figure 1.

circFBXO11 is highly expressed in HCC tissue and cells. A, CircRNA microarray unveiled the hundreds of circRNA with dysregulated expression in the HCC tissue as comparing to the normal control tissue. B, Volcano plot illustrated the up‐regulated and down‐regulated circRNAs in the high‐throughput sequencing. C, Schematic diagram revealed the genetic loci of circFBXO11 in the FBXO11 gene. D, Sanger sequencing confirmed the junction sites of exon 11 with exon 8. E, RT‐PCR showed the stability of circular transcript (circFBXO11) with the linear transcript (FBXO11 mRNA). F, RT‐PCR showed the circFBXO11 expression in the HCC tissue. G, Prognosis analysis showed the survival rate of HCC patients with high or low circFBXO11. Data are the means ± SD. **P < .01