Figure 2.

circFBXO11 promotes the tumour progress and OXA resistance of HCC cells. A, RT‐PCR showed that circFBXO11 expression in HCC cells B, RT‐PCR showed the circFBXO11 expression in the OXA‐resistant cells (HepG2/OXA) and normal cells (HepG2). C, The transfection of short hairpin RNA (shRNA) targeting the circFBXO11 could silence its expression in HepG2/OXA cells. D, The transfection of overexpression plasmid for circFBXO11 in HepG2 cells. E, OXA sensitivity analysis by CCK‐8 assay showed the 50% inhibitive concentration (IC50) of HepG2/OXA cells and HepG2 cells. F, Flow cytometry analysis revealed the cycle arrest of HepG2/OXA cells and HepG2 cells. G, Flow cytometry analysis revealed apoptosis of HepG2/OXA cells and HepG2 cells. H, In vivo heterograft mice assay indicated the tumour growth of HepG2/OXA cells with circFBXO11 knockdown. Data are the means ± SD. **P < .01