TABLE 2.
Information of candidate targets, their corresponding gene symbols and their degrees of correlation with compounds in the core network of anti‐ALI in PAF
| Symbol | Target name | UniProt ID | Degree | Betweenness centrality |
|---|---|---|---|---|
| PTGS2 | Prostaglandin‐endoperoxide synthase 2 | P35354 | 22 | 0.60031628 |
| PPARG | Peroxisome proliferator‐activated receptor gamma | P37231 | 6 | 0.39578975 |
| ADORA1 | Adenosine a1 receptor | P30542 | 5 | 0.28739429 |
| TNF | Tumour necrosis factor | P01375 | 5 | 0.01408255 |
| CASP3 | Caspase 3 apoptosis‐related cysteine protease | P42574 | 4 | 0.08883493 |
| NFE2L2 | Nuclear factor, erythroid 2‐like 2 | Q16236 | 3 | 0.11184012 |
| NFKB1 | Nuclear factor‐kappa B, subunit 1 | P19838 | 3 | 0.08275305 |
| ERBB2 | V‐erb‐b2 avian erythroblastic leukaemia viral oncogene homolog 2 | P04626 | 3 | 0.0601265 |
| TP53 | Tumour protein p53 | P04637 | 3 | 0.01703266 |
| MMP12 | Matrix metalloproteinase 12 | P39900 | 3 | 0.03610124 |
| ALOX5 | Arachidonate 5‐lipoxygenase | P09917 | 3 | 0.04091226 |