TABLE 3.
The key correlation pathway
| Term | Name | % | P value | Genes |
|---|---|---|---|---|
| hsa04066 | HIF‐1 signalling pathway | 25 | 1.00E‐07 | EGFR, CDKN1A, HIF1A, HMOX1, ERBB2, NFKB1, NOS2, STAT3 |
| hsa04668 | TNF signalling pathway | 21.875 | 4.37E‐06 | CASP3, TNF, PTGS2, MAPK14, CXCL2, IL1B, NFKB1 |
| hsa04621 | NOD‐like receptor signalling pathway | 15.625 | 8.04E‐05 | TNF, MAPK14, CXCL2, IL1B, NFKB1 |
| hsa04071 | Sphingolipid signalling pathway | 18.75 | 1.26E‐04 | TNF, MAPK14, TP53, NFKB1, ADORA1, PTEN |
| hsa04068 | FoxO signalling pathway | 18.75 | 2.12E‐04 | EGFR, CDKN1A, MAPK14, CAT, PTEN, STAT3 |
| hsa04010 | MAPK signalling pathway | 21.875 | 5.43E‐04 | EGFR, CASP3, TNF, MAPK14, TP53, IL1B, NFKB1 |
| hsa04620 | Toll‐like receptor signalling pathway | 15.625 | 9.40E‐04 | TNF, MAPK14, TLR2, IL1B, NFKB1 |
| hsa04210 | Apoptosis | 12.5 | .00216 | CASP3, TNF, TP53, NFKB1 |
| hsa04115 | p53 signalling pathway | 12.5 | .00269 | CDKN1A, CASP3, TP53, PTEN |
| hsa04064 | NF‐kappa B signalling pathway | 12.5 | .00563 | TNF, PTGS2, IL1B, NFKB1 |
| hsa04151 | PI3K‐Akt signalling pathway | 18.75 | .01354 | EGFR, CDKN1A, TP53, TLR2, NFKB1, PTEN |
| hsa04622 | RIG‐I‐like receptor signalling pathway | 9.375 | .03473 | TNF, MAPK14, NFKB1 |
| hsa04917 | Prolactin signalling pathway | 9.375 | .03564 | MAPK14, NFKB1, STAT3 |
| hsa04020 | Calcium signalling pathway | 12.5 | .03856 | EGFR, AGTR1, ERBB2, NOS2 |
| hsa04062 | Chemokine signalling pathway | 12.5 | .04246 | NCF1, CXCL2, NFKB1, STAT3 |