Table 3.
Summary of the comparative genomics studies conducted in adherent-invasive Escherichia coli to date
| Ref. | AIEC | Non-AIEC | Phylogroup | AIEC origin of isolation |
| Miquel et al[27], 2010 | 1 | 211 | AIEC: B2; Commensals: 4A, 2B1, 1B2; ExPEC: 2B1, 6B2, 3D, 3E | From an I-CD patient |
| Nash et al[28], 2010 | 2 | 101 | AIEC: B2; Commensals: 2A; ExPEC: 7B2, 1E | From I-CD patients |
| Dogan et al[31], 2014 | 24 | 25 | 14 strains from A phylogroup, 16 B1, 10 B2 and 9 D2 | From I-CD patients and controls |
| Desilets et al[32], 2015 | 143 | 6 | AIEC: A: 1; B1: 1; B2: 10; D: 1; F: 1. non-AIEC: A: 2; B1: 2; B2: 2 | From CD and UC patients[47] |
| Zhang et al[35], 2015 | 13 | 11 | AIEC: 1A, 1B1, 4B2, 1D, 5 Unknown. non-AIEC: 3A, 8 Unknown | From CD and UC patients and non-CD subjects |
| Deshpande et al[33], 2015 | 4 | 13071 | All B2 | From CD patients |
| O’Brien et al[34], 2015 | 11 | 30 | All B2, ST95 | From IBD patients and controls |
| Camprubí-Font et al[36], 2018 | 3 | 3 | AIEC: 1 B1, 1 B2 and 1 D. Non-AIEC: 1 B1, 1 B2 and 1 D | From CD patients and controls |
The strain collection examined according to pathotype and phylogroup is depicted. Adherent-invasive Escherichia coli origin of isolation and study observations are also presented.
1
Include commensals and ExPEC.
2
Human AIEC: 1A, 1B1, 1B2 and 1D; Murine AIEC: 1B1 and 1 B2; Dog AIEC: 2 B2; Human non-AIEC A phylogroup.
3
Apart from LF82, UM146 and NRG857c the other strains were only assessed for intramacrophage replication in J774 cells. AIEC: Adherent-invasive Escherichia coli; CD: Crohn’s disease; UC: Ulcerative colitis.