Table 4.
Genetic elements more frequently found in strains from the adherent-invasive Escherichia coli pathotype and suggested as putative adherent-invasive Escherichia coli molecular markers
| Marker |
Group of study (n) |
Prevalence (%) |
Sensitivity (%) | Specificity (%) | Accuracy (%) | ||
| AIEC | non-AIEC | AIEC | non-AIEC | ||||
| pduC[31]1 | 24 | 25 | 50 | 20 | 50 | 80 | 65 |
| lpfA[31]1 | 24 | 25 | 71 | 20 | 71 | 80 | 75 |
| 29 SNPs[33]2 | 4 | 1307 | 100 | 4 | - | - | - |
| lpfA + gipA[39] | 35 | 103 | 31 | 0 | 31 | 100 | 83 |
| 3 genomic regions[32]3 | 14 | 6 | 79 | 0 | 79 | 100 | 85 |
| chuA[13]4 | 15 | 37 | 93 | 59 | 93 | 41 | 56 |
| SNP algorithm[36] | 22 | 29 | - | - | 82 | 86 | 84 |
| pic + ampR[38] | 22 | 27 | 86 | 33 | 86 | 67 | 75 |
1
This strain collection was mainly formed by strains from A and B1 phylogroup (14 A, 16 B1, 10 B2 and 9D).
2
Only B2 strains were included. In this case, the non-AIEC group included commensal and ExPEC strains.
3
Only present in B2 AIEC strains. The strains’ phylogroup were: AIEC: 1 A, 1 B1, 10 B2, 1 D and 1 F; non-AIEC: 2 A, 2 B1 and 2 B2.
4
Strain collection with mainly B2 and D strains (11 A, 5 B1, 18 B2 and 18 D). AIEC: Adherent-invasive Escherichia coli.