Fig. 3.

Echocardiographic assessment of cardiac morphology and function in control and HSP60^CKO mice. The analysis were performed on left ventricular M-mode in control and HSP60^CKO mice prior to (pre), 4 weeks (4w), 6 weeks (6w), 9 weeks (9w), 11 weeks (11w), and 13 weeks (13w) post tamoxifen injection, respectively. a, b Measurement of left ventricular internal diameter at end-diastole (LVIDd) and at end-systole (LVIDs). c, d Measurement of interventricular septal wall thickness at end-diastole (IVSd) and at end-systole (IVSs). e, f Measurement of left ventricular posterior wall thickness at end-diastole (LVPWd) and at end-systole (LVPWs). g, h Quantitative analysis of left ventricular fractional shortening (FS) and ejection fraction (EF) of control and HSP60^CKO hearts. All Data represent mean ± SEM; n = 8–12 mice per group. Significance was determined using the two-way ANOVA analysis with Bonferroni post-hoc test. *p < 0.05, **p < 0.01, ***p < 0.001 versus control