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. 2019 Jun 17;27(2):587–600. doi: 10.1038/s41418-019-0374-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Proteomic analysis and validation of mitochondrial proteins in control and HSP60^CKO hearts 6 weeks post tamoxifen injection. a Pie chart showing functional classification of mitochondrial-localized proteins characterized from proteomic analysis and distribution of each functional category. b Numbers of differentially expression proteins (DEPs) including downregulated (Down) and upregulated (Up) proteins in each functional category. c Expression changes of individual mitochondrial proteins in HSP60^CKO hearts compared with control hearts revealed by the proteomic analysis. d Western blot analysis was used to validate expression changes of individual mitochondrial proteins in HSP60^CKO hearts. Mitochondria were isolated from control and HSP60^CKO hearts at 6 weeks (6w) and 11 weeks (11w) post tamoxifen injection, and total 10 proteins including HSP60, SUCLG2, LDHD, CPT2, ALDH2, BCKDHB, SIRT3, RTN4IP1, OXCT1, and VDAC1 were analyzed by western blot