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. 2020 May 7;11(5):330. doi: 10.1038/s41419-020-2548-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Representative μCT reconstructed images of trabecular bone from KO or control group. Scale bar, 200 μm (left image, sagittal view of metaphyseal region; top in right image, horizontal view; bottom, coronal view). b Quantification of BMD, BV/TV, Tb.Th, Tb.N, Tb.Sp, and SMI were measured. n = 6, *P < 0.05, **P < 0.01, ***P < 0.001. c Histological analysis of H&E, TRAP staining, and QKI, OCN IHC in femur metaphyseal region. Scale bar, 500 μm in left image in each group and 100 μm in right image in each group. d, e The data shown as the mean ± sd. OcS/BS osteoclast surface per bone surface, ObS/BS osteoblast surface per bone surface. n = 6, *P < 0.05, **P < 0.01. f Serum Acp5 and OCN abundance in KO and control mice. n = 6, *P < 0.05.