Table 4.
Multivariate Poisson regression analysis
| Gait speed | Cognitive status | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 1➔0 | 1➔0 | ||||||||
| Variable | IRR | Std. error | pvalue | 95% CI | Variable | IRR | Std. error | pvalue | 95%CI |
| Female | Female | ||||||||
| Age | 1.048 | 0.012 | 0.000 | 1.024–1.072 | Age | 1.002 | 0.019 | 0.910 | 0.966–1.040 |
| APOE4 | 0.908 | 0.198 | 0.659 | 0.592–1.394 | APOE4 | 0.876 | 0.246 | 0.638 | 0.506–1.519 |
| Insulin | 1.325 | 0.163 | 0.022 | 1.041–1.685 | Education | 0.932 | 0.059 | 0.263 | 0.824–1.054 |
| Male | Male | ||||||||
| Age | 1.056 | 0.018 | 0.001 | 1.021–1.091 | Age | 1.010 | 0.034 | 0.781 | 0.944–1.079 |
| APOE4 | 1.331 | 0.333 | 0.253 | 0.815–2.175 | APOE4 | 1.136 | 0.405 | 0.720 | 0.565–2.284 |
| Creatinine | 0.520 | 0.137 | 0.013 | 0.310–0.870 | Education | 0.951 | 0.087 | 0.583 | 0.794–1.138 |
| Leptin | 7.539 | 6.814 | 0.025 | 1.282–44.34 | |||||
| Triglyceride | 0.299 | 0.152 | 0.017 | 0.110–0.809 | |||||
| 0➔0 | 0➔0 | ||||||||
| Female | Female | ||||||||
| Age | 0.948 | 0.005 | 0.000 | 0.938–0.958 | Age | 0.985 | 0.012 | 0.196 | 0.961–1.008 |
| APOE4 | 0.972 | 0.079 | 0.732 | 0.829–1.141 | APOE4 | 1.144 | 0.145 | 0.288 | 0.893–1.466 |
| % Body fat | 0.793 | 0.056 | 0.001 | 0.691–0.910 | Education | 1.059 | 0.028 | 0.032 | 1.005–1.116 |
| LDH | 0.623 | 0.060 | 0.000 | 0.514–0.752 | LDH | 0.276 | 0.144 | 0.013 | 0.099–0.765 |
| Male | Male | ||||||||
| Age | 0.961 | 0.007 | 0.000 | 0.948–0.974 | Age | 0.985 | 0.010 | 0.148 | 0.966–1.005 |
| APOE4 | 0.870 | 0.098 | 0.217 | 0.697–1.085 | APOE4 | 0.844 | 0.110 | 0.193 | 0.653–1.089 |
| Cholesterol | 1.394 | 0.135 | 0.001 | 1.154–1.684 | Education | 1.021 | 0.032 | 0.512 | 0.960–1.086 |
| APSM | 1.516 | 0.265 | 0.017 | 1.076–2.135 | |||||
| 0➔1 | 0➔1 | ||||||||
| Female | Female | ||||||||
| Age | 1.041 | 0.014 | 0.003 | 1.014–1.069 | Age | 1.020 | 0.021 | 0.335 | 0.979–1.063 |
| APOE4 | 1.102 | 0.255 | 0.673 | 0.699–1.737 | APOE4 | 0.999 | 0.295 | 1.000 | 0.560–1.784 |
| Leptin | 1.389 | 0.226 | 0.043 | 1.010–1.911 | Education | 0.856 | 0.856 | 0.037 | 0.740–0.990 |
| Male | Male | ||||||||
| Age | 1.066 | 0.023 | 0.003 | 1.022–1.111 | Age | 1.070 | 0.037 | 0.054 | 0.999–1.146 |
| APOE4 | 1.140 | 0.353 | 0.671 | 0.621–2.093 | APOE4 | 1.936 | 0.711 | 0.072 | 0.942–3.977 |
| IGF-1 | 1.737 | 0.419 | 0.022 | 1.082–2.787 | Education | 1.053 | 0.104 | 0.600 | 0.867–1.280 |
Age and APOE4 were used to adjust in the final gait speed multivariate model. Age, APOE4 and education are used to adjust in the final cognitive status multivariate model. APOE4 apolipoprotein E4, LDH lactate dehydrogenase, APSM appendicular skeletal muscle mass