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. 2020 May 7;11(5):329. doi: 10.1038/s41419-020-2557-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Schematic illustration of the Meis1-binding sites in the potential SNORD3A promoter predicted by JASPAR database (http://jaspar.binf.ku.dk). b, c qRT-PCR was performed to detect the expression levels of Meis1 in breast cancer cell lines (b) and in paired breast cancer tissues and normal mammary tissues (n = 26) (c). d The correlation between Meis1 and SNORD3A expression in breast cancer tissues was analyzed. e, f Meis1 overexpression resulted in elevated mRNA level of SNORD3A (e) and protein level of UMPS in MCF-7 and MDA-MB-231 cells (f). g Enrichment of Meis1 protein on the SNORD3A promoter was determined by ChIP-qPCR assay. Student’s t test, mean ± s.d. **p < 0.001, ***p < 0.001, ****p < 0.0001.