Fig. 3.
The potential therapeutic strategies (red font) for the treatment of HGPS with their target molecular/physiological pathways. Abbreviations: 1,25D, 1α,25-dihydroxy vitamin D3; AFC, N-acetyl-S-farnesyl-l-cysteine; ATRA, all-trans retinoic acid; CRISPR, clustered regularly interspaced short palindromic repeats; FTI, farnesyl transferase inhibitors; ICMT, isoprenylcysteine carboxyl methyltransferase; iPSC-EVs, extracellular vesicles derived from induced pluripotent cells; mono-AP, mono-aminopyrimidines; NF-κB, nuclear factor kappa B; ROS, reactive oxygen species; ROCK, Rho-associated protein kinase