Table 2.
Loss of p53 does not rescue lethality induced by Siva deficiency
| Siva | +/+ | +/+ | +/+ | +/− | +/− | +/− | −/− | −/− | −/− | ND | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| p53 | +/+ | +/− | −/− | +/+ | +/− | −/− | +/+ | +/− | −/− | ||||
| Age | Litters | Total | P value | ||||||||||
| e10.5 | 10 | 84 | 6 (5.25) | 12 (10.5) | 8 (5.25) | 14 (10.5) | 25 (21) | 11 (10.5) | 1 (5.25) | 3 (10.5) | 0 (5.25) | 6 | <2 × 10−3 |
| P1.5 | 10 | 71 | 7 (4.4375) | 11 (8.875) | 4 (4.4375) | 10 (8.875) | 24 (17.75) | 13 (8.875) | 0 (4.4375) | 0 (8.875) | 0 (4.4375) | 2 | <1 × 10−5 |
| P21 | 9 | 54 | 5 (3.375) | 7 (6.75) | 4 (3.375) | 9 (6.75) | 20 (13.5) | 9 (6.75) | 0 (3.375) | 0 (6.75) | 0 (3.375) | NA | <2 × 10−5 |
The actual (and expected) numbers of embryos and pups recovered from Siva;p53-heterozygous intercrosses at the indicated embryonic (e) and postnatal (P) ages. ND includes decidua from which embryos could not be isolated and embryos for which genotype could not be determined. P values denote significant loss of Siva−/−;p53−/− embryos and pups as determined by Χ2 test