Table 3.
Rip3 loss does not rescue lethality induced by Siva deficiency
| Siva | +/+ | +/+ | +/+ | +/− | +/− | +/− | −/− | −/− | −/− | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Rip3 | +/+ | +/− | −/− | +/+ | +/− | −/− | +/+ | +/− | −/− | |||
| Age | Litters | Total | P value | |||||||||
| e10.5 | 9 | 62 | 5 (3.875) | 15 (7.75) | 7 (3.875) | 9 (7.75) | 15 (15.5) | 8 (7.75) | 1 (3.875) | 1 (7.75) | 1 (3.875) | <0.01 |
| P21 | 15 | 92 | 6 (5.75) | 14 (11.5) | 11 (5.75) | 17 (11.5) | 31 (23) | 13 (11.5) | 0 (5.75) | 0 (23) | 0 (5.75) | <4× 10−5 |
The actual (and expected) numbers of embryos and pups recovered from Siva;Rip3-heterozygous intercrosses at embryonic (e) day 10.5 and postnatal (P) day 21. P values denote significant loss of Siva−/−;Rip3−/− embryos and pups as determined by Chi-square test