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. 2020 May 7;10:7714. doi: 10.1038/s41598-020-64880-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Vitamin K2 triggers AMPK-dependent autophagic cell death in vivo. (A) Tumor volume changed during administration with or without 10, 20 mg/kg Vitamin K2 every day for 33 days. (B) Mice weight changed during administration with or without 10, 20 mg/kg Vitamin K2. (C) The mice survival rates after administration with or without Vitamin K2. (D,E) Immunohistochemistry (IHC) showed the changes of relevant proteins expression in Vitamin K2-treated tumors, scale bar: 20 μm. (F) Western blot showed the effect of Vitamin K2 on the expression of relevant proteins in tumors. (G) The schematic diagram of metabolic signal axis involved in Vitamin K2-induced AMPK dependent autophagic cell death. Data represent the mean ± SD of three different experiments with triplicate sets in each assay. *P < 0.05, **P < 0.01 and ***P < 0.001.