Fig. 6.

JOSD1 and myeloid cell leukaemia 1 (MCL1) expression correlates with chemoresistance and poor prognosis of ovarian cancer patients. a Representative images of JOSD1 and MCL1 staining in platinum-sensitive and platinum-resistant ovarian cancer samples. Scale bars, 250 μm. b Correlation analysis of JOSD1 and MCL1 expression levels in ovarian cancer samples (n = 150). Pearson correlation coefficients are shown. c, d Correlation between JOSD1 expression (c) or MCL1 expression (d) and overall survival or progression-free survival in ovarian cancer patients (n = 150). Kaplan–Meier survival plots are shown. e Immunoblotting for JOSD1 in the supernatants of chemoresistant cell lines and their parental cell lines. f Correlation between serum JOSD1 levels and intratumour JOSD1 expression in 20 paired serum and tumour tissue samples. Pearson correlation coefficients are shown