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. 2019 Jun 3;27(1):269–283. doi: 10.1038/s41418-019-0355-0

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© ADMC Associazione Differenziamento e Morte Cellulare 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Concomitant loss of Men1 and Pten accelerated pancreatic neuroendocrine tumor development in MPM mice. a Quantitative measurements of the ratio of the islet area per pancreas area in MP (n = 6), MPM (n = 6) mice of 11 weeks, and MM (n = 4) and PM (n = 6) mice of 18–19 weeks. b Quantitative measurements of the ratio of the islets area per pancreas area in MP (n = 3), MR (n = 3), PR (n = 3), and MPR (n = 5) mice of 15 weeks. c Quantitative measurements of the ratio of the islets area per pancreas area of treated mice in preclinical rapamycin assessment. Vehicle-treated mice (V) at 9 weeks (n = 6), Rapamycin-treated mice (R) at 9 weeks (n = 5), Vehicle-treated mice (V) at 12 weeks (n = 6), Rapamycin-treated mice (R) at 12 weeks (n = 8). MPM Men1^flox/flox Pten^flox/flox MIP-Cre, MP Men1^flox/flox Pten^flox/flox, MM Men1^flox/flox MIP-Cre, PM Pten^flox/flox MIP-Cre, MPR Men1^flox/flox Pten^flox/flox RIP-Cre, MR Men1^flox/flox RIP-Cre, PR Pten^flox/flox RIP-Cre