Table 1.
MICs (µg/mL) of auranofin and control antibiotics against C. difficile clinical isolates at standard and high inocula.
| C. difficile strains | Auranofin | Vancomycin | Fidaxomicin | |||
|---|---|---|---|---|---|---|
| SI | HI | SI | HI | SI | HI | |
| ATCC BAA 1870 | 1 | 1 | 1 | 1 | 0.03 | 0.03 |
| ATCC 43255 | 0.5 | 0.5 | 1 | 2 | 0.015 | 0.015 |
| NR-49277 | 0.5 | 0.5 | 1 | 2 | 0.03 | 0.03 |
| NR-49278 | 0.25 | 0.25 | 0.25 | 1 | 0.007 | 0.007 |
| NR-49281 | 0.25 | 0.25 | 0.25 | 1 | 0.007 | 0.015 |
| NR-49284 | 0.25 | 0.25 | 0.25 | 1 | 0.015 | 0.015 |
| NR-49285 | 0.5 | 0.5 | 0.5 | 1 | 0.015 | 0.03 |
| NR-49286 | 0.25 | 0.25 | 0.25 | 0.25 | 0.007 | 0.007 |
| NR-49288 | 0.25 | 0.5 | 0.5 | 1 | 0.007 | 0.03 |
| NR-49290 | 0.25 | 0.25 | 0.5 | 1 | 0.015 | 0.015 |
| MIC90 | 0.5 | 0.5 | 1 | 2 | 0.03 | 0.03 |
SI, standard inoculum (∼5 × 105 CFU/mL); HI, high inoculum (∼5 × 107 CFU/mL); MIC90, the concentration of the test agent that inhibited the growth of 90% of the tested strains.