Fig. 1.

The PVT1 lncRNA is upregulated in NPC and is associated with a poor prognosis in patients. a Expression of PVT1 mRNA is higher in NPC cell lines compared with the immortalized nasopharyngeal epithelial cell line. b Expression levels of PVT1 mRNA in ten clinical NPC tumors and ten freshly frozen normal nasopharyngeal specimens. c, d Expression levels of PVT1 mRNA in NPC tumors and normal nasopharyngeal specimens. PVT1 mRNA-expression data were obtained from the GSE12452 dataset [21] and the GSE64634 dataset [22] and analyzed. e, f, Kaplan–Meier analysis of relapse-free survival (RFS) and over survival (OS) for patients with high PVT1 mRNA-expression NPC versus low PVT1 mRNA-expression NPC. Error bars ± SD. **P < 0.01. ***P < 0.001. Data are representative from three independent experiments