Fig. 5.

PVT1 stabilizes HIF-1α via KAT2A. a Effects of PVT1 knockdown on HIF-1α protein in HNE-1 and CNE-1 NPC cells. b Quantification of HIF-1α protein in a. c Effects of PVT1 knockdown on HIF-1α mRNA in HNE-1 and CNE-1 NPC cells. d Overexpression of KAT2A restores PVT1 knockdown-inhibited HIF-1α protein. e Quantification of HIF-1α and KAT2A proteins in d. Overexpression of KAT2A restores PVT1 knockdown-inhibited HIF-1α mRNA (f), HIF-1α mRNA stability (g), NPC cell proliferation (h), and colony formation (i). Error bars ± SD. **P < 0.01. ***P < 0.001. Data are representative from three independent experiments