Fig. 1.

FNDC5 attenuated doxorubicin (DOX)-induced cardiac dysfunction in mice. a Fractional shortening (FS) of mice as determined via echocardiography 8 days after DOX injection (n = 8). b Hemodynamic parameter of mice with or without FNDC5 overexpression (n = 8). c Statistical results of the heart weight/tibia length ((HW/TL) (n = 8). (d) Body weight alterations (n = 8). e–g Biochemical determination of cTnT, LDH, CK-MB serum levels (n = 10). Values represent the mean ± SEM. *P < 0.05 versus the corresponding normal saline (NS) group mice injected with negative control (NC) adeno-associated virus 9, ^#P < 0.05 versus DOX-treated mice injected with AAV9-NC