Fig. 2.

FNDC5 suppressed oxidative stress and cardiomyocyte apoptosis in DOX-treated mice. a, b Representative DHE, 4-HNE staining images and the quantitative results (n = 6). c, d Western blots and statistical results (n = 6). e Quantitative results of myocardial MDA, GSH levels and SOD, NADPH oxidase activities (n = 6). f, g TUNEL staining and the quantitative results (n = 8). h, i Western blots and the statistical results of apoptosis-related proteins (n = 6). Values represent the mean ± SEM. *P < 0.05 versus the corresponding normal saline (NS) group mice injected with negative control (NC) adeno-associated virus 9, ^#P < 0.05 versus DOX-treated mice injected with AAV9-NC