Fig. 7.

circUHRF1/miR-526b-5p/c-Myc/TGF-β1/ESRP1 feedback loop regulates the OSCC metastasis. a, b The invasive and migrative ability of SCC25 cells was tested using the transwell assay with the transfection of miR-526b-5p inhibitor, circUHRF1 shRNA (sh-circUHRF1), c-Myc siRNA (si-c-Myc), and ESRP1 pcDNA plasmid (pcDNA–ESRP1). c The DNA synthesis measured by EdU assay. d The protein markers of EMT were detected using western blot analysis, including mesenchymal markers (N-cadherin, Vimentin) and the epithelial marker (E-cadherin). **p-value < 0.01