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. 2020 May 7;11(5):335. doi: 10.1038/s41419-020-2549-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Schematic graph showing the identification of differentially expressed RNAs after analyzing two GEO databases (GSE54238 for Wang’s cohort, GSE40144 for Li’s cohort). b Flowchart showing the identification of NT5DC2, UBE2C and hepsin as candidate genes. Twelve genes were found significantly associated with OS and DFS in Li’s cohort. Further cross-validation of patient OS using K–M plot identified NT5DC2, UBE2C and hepsin as candidate genes. c Candidate genes significantly associated with patient’s OS in K–M plot database (http://www.kmplot.com/). d NT5DC2 expression in normal liver, inflammatory liver, liver with cirrhosis, early HCC and advanced HCC in Wang’s cohort. Student’s t-tests were performed to analyze the differences between each group and normal liver. P values are labeled above the column for each group. e NT5DC2 expression in TNM stage I patients, stage II patients and stage III patients in Li’s cohort. Student’s t-tests were performed to analyze the differences between each group and TNM stage I patients. P values are labeled above the column for each group.