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. 2019 Jul 1;27(2):646–661. doi: 10.1038/s41418-019-0378-6

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© The Author(s), under exclusive licence to ADMC Associazione Differenziamento e Morte Cellulare 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Interaction among EMC subunits. a S2 cells were transiently transfected with emc3-RFP, emc5-mCherry, or emc6-GFP, or co-transfected with emc3-RFP/emc6-GFP, emc5-mCherry/emc6-GFP, emc6-GFP/RFP-rab7. EMC6 puncta are indicated by arrows. Scale bar is 5 μm. b Flowchart of Tandem Mass Tags Labeling coupled with LC-MS/MS for the comparative analysis of protein levels in retina of emc2 (GMR-Gal4/UAS-emc2A^RNAi), emc4 (GMR-Gal4/UAS-emc4^RNAi), emc5 (GMR-Gal4/UAS-emc5^RNAi), and emc7 (FRT42D emc7¹) mutant flies, as well as wild-type (GMR-gal4) flies. c Venn diagrams showing the overlap of proteins that were downregulated > 50% among the four analyzed genotypes: emc2, emc4, emc5, and emc7