Comparison 3. 5‐FU 5% versus Podophylin.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
3.1 Cure	2		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
3.1.1 Total cure	2	156	Risk Ratio (M‐H, Random, 95% CI)	1.26 [0.86, 1.82]
3.1.2 Podophylin 2%	1	114	Risk Ratio (M‐H, Random, 95% CI)	1.48 [1.03, 2.12]
3.1.3 Podophylin 4%	1	79	Risk Ratio (M‐H, Random, 95% CI)	1.17 [0.56, 2.43]
3.1.4 Podophylin 25%	1	37	Risk Ratio (M‐H, Random, 95% CI)	0.96 [0.55, 1.69]
3.2 Absence of Response	1		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
3.2.1 Podophylin 2% plus Podophylin 4%	1	119	Odds Ratio (M‐H, Random, 95% CI)	0.42 [0.18, 0.96]
3.2.2 Podophylin 2%	1	114	Odds Ratio (M‐H, Random, 95% CI)	0.38 [0.16, 0.89]
3.2.3 Podophylin 4%	1	79	Odds Ratio (M‐H, Random, 95% CI)	1.02 [0.11, 9.78]
3.3 Recurrence of Lesion	1	150	Risk Ratio (M‐H, Random, 95% CI)	3.89 [2.29, 6.61]
3.4 Side Effects	1		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
3.4.1 2% plus 4%	1	119	Risk Ratio (M‐H, Random, 95% CI)	1.82 [0.99, 3.37]
3.4.2 Podophylin 2%	1	114	Risk Ratio (M‐H, Random, 95% CI)	2.32 [1.12, 4.79]
3.4.3 Podophylin 4%	1	79	Risk Ratio (M‐H, Random, 95% CI)	0.68 [0.31, 1.45]