Wallin 1977.

Study characteristics
Methods	Parallel Randomized Controlled Trial, Ctegory A, Jadad 3
Participants	Forty two men with condyloma acuminata whose ages ranged between 19 and 36 years (mean 24 years) were allocated in two treatment groups that were described as similar in age, marital status, size of warts and warts distribution
Interventions	1) 5‐FU Group ‐ 5‐FU cream 5% self‐applied every night for 2 weeks, n=20 2) Podophyllin Group ‐ Podophyllin 25% solution applied to the warts by the doctor once a week for four consecutive weeks, n=22
Outcomes	1) Failure ‐ defined as total absence of response 2) Recurrence ‐ defined as reappearance of lesions during treatment after a initial response, in the follow up 3) Cure ‐ defined as disappearance of genital warts
Notes	Follow up was done by 4 weeks
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "The patients were allocated in two treatment groups using a table of random numbers." Comment: Probably done
Allocation concealment (selection bias)	Low risk	Quote: "...using a table of random numbers." Comment: Probably done
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Not described Comment: Problaby not done