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. 2020 Feb 17;18(2):219–228. doi: 10.5217/ir.2019.00037

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© Copyright 2020. Korean Association for the Study of Intestinal Diseases. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 1. — The mRNA expression of PAI-1 is elevated in the terminal ileum of CD patients. The mRNA expression of PAI-1 (PAI-1), Col1A1 (COL1A1), Col1A2 (COL1A2) and TGF-β1 (TGF-β1) genes in the ileal tissue from control subjects (n=11), patients with inactive CD (n=16) and active CD (n=51). Data were derived from a Gene Expression Omnibus (GEO) dataset GSE75214. (A) The expression of PAI-1 (PAI-1) was significantly upregulated in the terminal ileal mucosa of active CD patients compared with that of normal controls or inactive CD patients. (B) COL1A1 and TGF-β1 are positively correlated. Correlation coefficient between PAI-1 and Col1A1 or Col1A2 are 0.73 or 0.75. P-value by Kruskal-Wallis test. Correlation of 2 values using Pearson correlation coefficient. ^a P<0.001. PAI-1, plasminogen activator inhibitor-1; TFG-β, transforming growth factor β.