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. 2020 Apr 18;3(2):80–94. doi: 10.1093/abt/tbaa006

Table 1.

Known affinities of CD47-SIRPα ligands

Ligand Receptor Affinity (μM) Reference
SIRPαV1 CD47 0.46/0.74 Rodriguez [39]/Hatherley [38]
SIRPαV2 CD47 1.0–2.0 Brooke [8], Hatherley [104], Hatherley [14]
SIRPαV2 CD47 0.44/0.64 Rodriguez [39]/Hatherley [38]
SIRPαV3 CD47 0.84 Rodriguez [39]
SIRPαV4 CD47 0.91 Rodriguez [39]
SIRPαV5 CD47 2.50/0.78 Rodriguez [39]/Hatherley [38]
SIRPαV6 CD47 0.30 Rodriguez [39]
SIRPαV7 CD47 3.21/0.65 Rodriguez [39]/Hatherley [38]
SIRPαV8 CD47 0.65 Rodriguez [39]
SIRPαV9 CD47 1.14 Rodriguez [39]
SIRPαV10 CD47 0.08/0.67 Rodriguez [39]/Hatherley [38]
NOD SIRPα CD47 0.08 Kwong [31]
‘Self’ peptide SIRPα 0.16 Rodriguez [39]
FD6 CD47 4.1 Inline graphic 10 -5 Weiskopf [55]
CV1 CD47 1.1 Inline graphic 10–5 Weiskopf [55]
PKHB1 (peptide) CD47 ‘micromolar’ affinity Martinez-Torres [105]
CD47AP SIRPα 1.1 Inline graphic 10–2 Lee [94]
N3612 (Velcro CD47) SIRPαV1 2.5 Inline graphic 10−3 Ho [96]
SIRPαV2 3.7 Inline graphic 10−4
DSP-107 (SIRPα-41BBL) CD47 1.5 Inline graphic 10−3 Gozlan [106]