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. Author manuscript; available in PMC: 2020 May 8.
Published in final edited form as: Sci Signal. 2019 Jul 30;12(592):eaax3938. doi: 10.1126/scisignal.aax3938

Fig 5. Relationship between growth and antibiotic tolerance in nutritional auxotrophs and relA spoT strains.

Fig 5.

(A) Fraction of surviving wild-type (14028s), manA (MP50) and trpEDCBA::Tn10 (AS301) Salmonella following 24 h treatment with either cefotaxime (200 μg/mL) or ciprofloxacin (2 μg/mL) under growth-permissive and growth-restrictive conditions (see Materials and Methods). Fraction of surviving (B) wild-type (14028s) and relA::Tn10 spoT trpA::kan (MP1494), or (C) wild-type (14028s) and relA::Tn10 spoT (MP342) Salmonella following 24 h treatment with cefotaxime (200 μg/mL) under growth-permissive and growth-restrictive conditions (see Materials and Methods). Error bars represent standard deviations (N = 8 biological replicates). Note log scale of y axis. Wilcoxon rank-sum test between populations at the edge of brackets: ****p<0.0001 and N.S. for no significance.