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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Brain Res Bull. 2020 Mar 21;159:16–24. doi: 10.1016/j.brainresbull.2020.03.004

Fig. 5. Minocycline attenuated neuroinflammation induced by noise or the combination of surgery and noisy environment.

Fig. 5.

Seven-week old mice were subjected to right carotid exploration and 75 db noisy environments with or without the treatment of minocycline. Hippocampus was harvested at 6 h after surgery or the last episode of noise. A: The abundance of IL-1β and IL-6 in the hippocampus. B: Representative immunostaining images of Iba-1 in CA1. C: Representative immunostaining images of Iba-1 in CA3. D: Representative immunostaining images of Iba-1 in cerebral cortex. E: Graphic presentation of the percentage area that is Iba-1-postive staining in CA1, CA3 and cerebral cortex. Scale bar = 30 μm. Results are means ± S.E.M. (n = 6). * P < 0.05 compared with control group; ^ P < 0.05 compared with noise group; # P < 0.05 compared with surgery plus noise group.