Fig. 4.

Treatment benefit score (TBS) of seven actionable genes in responders versus nonresponders. a Relative TBS of seven actionable genes compared across 9 responders and 211 nonresponders. Scores were calculated as individual values for mTOR, VEGFR2, c-KIT, and c-RAF, as well as paired values from mTOR with VEGFR2 and c-KIT with c-RAF. The thick line in each box is the median. Circles extend to the most extreme data point, no more than 1.5 times the interquartile range. * p < 0.05, ** p < 0.01. b, c Receiver operating ­characteristic curve analysis to predict the response to sorafenib (TBS) per gene (b) and per pair (c). cmTOR_VEGFR2_c-KIT_c-RAF.