Table 3.
Definition of staging systems and survival outcomes
| T criteria | N category | M category | DSS, months, median (95% CI) | Five-year DSS,% | |
|---|---|---|---|---|---|
| AJCC 8th | |||||
| Stage IA | Solitary tumor ≤2 cm | N0 | M0 | 210.5 (178.9–NE) | 87.7 |
| Stage IB | Solitary tumor >2 cm without mvi | N0 | M0 | 159.4 (131.8–NE) | 83.7 |
| Stage II | Solitary tumor >2 cm with mvi or multiple tumors, none >5 cm | N0 | M0 | 105.7 (92.8–119.8) | 75.2 |
| Stage IIIA | Multiple tumors, at least one of which is >5 cm | N0 | M0 | NE | 54.4 |
| Stage IIIB | Single tumor or multiple tumors of any size involving a major branch of the portal vein or hepatic vein, or tumor(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum | N0 | M0 | 22.3 (15.0–93.4) | 43.6 |
| Stage IVA | Any T | N1 | M0 | 18.0 (3.8–161.5) | 46.7 |
| Stage IVB | Any T | Any N | M1 | 11.0 (2.6–17.1) | 0 |
| New staging | |||||
| Stage IA | None of following factors | N0 | M0 | 219.7 (187.9–NE) | 89.7 |
| Stage IB | One of following factors | N0 | M0 | 137.2 (122.9–NE) | 83.0 |
| Stage II | Two of following factors | N0 | M0 | 114.8 (88.6–154.0) | 72.7 |
| Stage III | Three of following factors | N0 | M0 | 72.2 (33.2–NE) | 58.7 |
| • Size >2 cm | |||||
| • Multiple tumors | |||||
| • mvi | |||||
| Stage IVA | Single tumor or multiple tumors of any size involving a major branch of the portal vein or hepatic vein, or tumor(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum Any T | N0 N1 |
M0 M0 |
30.6 (18.0–161.5) | 47.1 |
| Stage IVB | Any T | Any N | M1 | 11.0 (2.6–17.1) | 0 |
DSS, disease-specific survival; AJCC, American Joint Committee on Cancer; NE, not estimated; mvi, microvascular invasion.