Table 3.

Summary of the results of JCPyV studies on CRC patients and controls (n = 17)

Study [Ref.], year	Country	Study design	Sample type	CRC tissue			Control			Analysis method	Target region
				total	positive	prevalence	total	positive	prevalence
Laghi et al. [37], 1999	USA	Case series	Fresh tissue	46	12	26.1%	−	−	−	Nested PCR	T-Ag
Enam et al. [17], 2002	USA	Case series	FFPE tissue	27	22	81.5%	−	−	−	PCR	T-Ag	Agnoprotein
Newcomb et al. [20], 2004	USA	Case series	FFPE tissue	233	0	0%	233	1	0.4%	TaqMan assay, nested PCR	T-Ag	VP, regulatory region
Casini et al. [14], 2005	Italy	Case series	FFPE tissue	18	15	83.3%	16	13	81.2%	PCR, ISH	T-Ag
Hori et al. [15], 2005	Japan	Case-control	FFPE tissue	23	6	26.1%	20	0	0%	Nested PCR	T-Ag VP, agnoprotein
Theodoropoulos et al. [16], 2005	Greece	Case-control	FFPE and fresh tissue	80	49	61.3%	20	6	30%	Nested PCR, qPCR	T-Ag
Goel et al. [38], 2006	USA	Case series	FFPE tissue	100	77	77%	−	−	−	PCR	T-Ag
Lin et al. [18], 2008	Taiwan	Case series	FFPE tissue	22	19	86.4%	22	0	0%	Nested PCR	T-Ag
Campello et al. [21], 2010	Italy	Case-control	Fresh tissue	94	0	0%	91	0	0%	qPCR	T-Ag
Vilkin et al. [40], 2012	Israel	Case series	FFPE tissue	30	6	20%	30	3	10%	PCR	T-Ag
Mou et al. [13], 2012	China	Case series	Fresh tissue	137	56	40.9%	137	34	24.8%	Nested PCR	T-Ag
Coelho et al. [41], 2013	Portugal	Case-control	Fresh tissue	14	12	85.7%	100	40	40%	Nested PCR	T-Ag
Samaka et al. [42], 2013	Egypt	Case-control	FFPE tissue	57	23	40.4%	10	2	20%	ISH	T-Ag
Sinagra et al. [25], 2014	Italy	Case-control	FFPE tissue	19	4	21%	10	0	0%	Nested PCR	T-Ag
Ksiaa et al. [39], 2015	Tunisia	Case series	FFPE tissue	105	61	58.1%	89	13	14.6%	PCR	T-Ag
Toumi et al. [43], 2017	Tunisia	Case-control	Fresh tissue	47	22	46%	20	0	0%	Nested PCR	T-Ag
Sarvari et al. [36], 2018	Iran	Case-control	FFPE tissue	70	1	1.4%	70	0	0%	PCR	T-Ag

JCPyV, JC polyomavirus; CRC, colorectal cancer; FFPE, formalin-fixed paraffin-embedded; ISH, in situ hybridization; T-Ag, tumor antigen.