Table 3.

Univariate and multivariate Cox regression analyses to find independent predictors of overall survival rate in patients with colorectal cancer

Clinicopathological factors	Univariate		Multivariate
	HR (95% CI)	p value	HR (95% CI)	p value
Age (≤60 years/>60 years)	0.84 (0.50–1.42)	0.515	0.66 (0.56–1.97)	0.88
Gender (male/female)	1.32 (0.77–2.73)	0.30	1.18 (0.64–2.18)	0.58
Tumor size (>5cm vs. ≤5cm)	2.15 (1.25–3.70)	0.005	1.06 (0.59–1.89)	0.84
TNM stage (III+IV/0+I+II)	55.57 (6.42–481.29)	0.0001	2.55 (1.63–4.00)	0.001
Tumor grade (III/I+II)	3.11 (1.85–5.25)	0.0001	1.40 (0.89–2.19)	0.14
Distant metastasis (M1/M0)	8.03 (4.02–16.03)	0.0001	2.31 (0.96–5.54)	0.06
Lymphatic invasion (positive/negative)	2.37 (1.32–4.25)	0.004	1.72 (0.69–4.28)	0.24
Vascular invasion (positive/negative)	1.98 (1.16–3.39)	0.013	1.64 (0.31–3.39)	0.26
PPARα expression level (high/low)	6.52 (3.35–12.68)	0.0001	2.39 (1.09–5.20)	0.03
PPARγ expression level (high/low)	0.14 (0.07–0.27)	0.0001	0.37 (0.17–0.83)	0.02
PPARδ expression level (high low)	6.41 (3.29–12.45)	0.0001	2.37 (1.09–5.14)	0.03

TNM, tumor node metastasis; CI, confidence interval; HR, hazard ratio.