Table 1.

Selected patient and transplant characteristics of melanoma cases and matched controls, Center for International Blood and Marrow Transplant Research program, 1985–2012.

Characteristic	Melanoma cases (n=140)		Matched controls (n=557)
	n	%	n	%
Age at transplant,* years
<40	54	38.6	214	38.4
40-<55	48	34.3	190	34.1
≥55	38	27.1	153	27.5
Sex*
Male	79	56.4	316	56.7
Female	61	43.6	241	43.3
Indication for transplant*
ALL	25	17.9	100	18.0
AML	25	17.9	100	18.0
MDS	13	9.3	52	9.3
Other acute leukemia	1	0.7	4	0.7
CML	34	24.3	136	24.4
CMML	2	1.4	8	1.4
MPN	9	6.4	36	6.5
CLL	12	8.6	48	8.6
NHL	17	12.1	65	11.7
HL	1	0.7	4	0.7
MM	1	0.7	4	0.7
Region**
United States	118	84.3	430	77.2
Canada	15	10.7	88	15.8
Europe	3	2.1	20	3.6
Australia/New Zealand	4	2.9	19	3.4
Ambient UVR**
Tertile 1	42	30.0	197	35.4
Tertile 2	41	29.3	185	33.2
Tertile 3	57	40.7	175	31.4
Karnofsky score prior to preparative regimen
≥90	108	77.1	410	73.6
<90	29	20.7	114	20.5
Missing	3	2.1	33	5.9
Transplant year
1985–1998	37	26.4	203	36.4
1999–2005	57	40.7	173	31.1
2006–2012	46	32.9	181	32.5
Donor age, median (range), years	36 (5–70)		36 (<1–73)
Time from transplant to melanoma/study inclusion,* median (range), years	4 (<1–24)		4(<1–24)

Abbreviations: ALL - acute lymphocytic leukemia; AML - acute myeloid leukemia; CLL - chronic lymphocytic leukemia; CML - chronic myeloid leukemia; CMML - chronic myelomonocytic leukemia; HL - Hodgkin lymphoma; MDS - myeloproliferative disorder; MM - multiple myeloma; MPN - myeloproliferative neoplasm; mW/m² - milliWatt per square meter; NHL - non-Hodgkin lymphoma; UVR - ultraviolet radiation.

^*Four controls were matched to each case by age (± 3 years), sex, first primary disease, and survival time without developing melanoma at least as long as the matched case’s interval from transplant to melanoma.

^**Ambient UVR was based on the region of patient residence, measured as radiation intensity (mW/m²) and divided into tertiles. If zip code was not available, nearest transplant center was used. Tertile 1: <23.0 mW/m²; Tertile 2: 23.0-<31.6 mW/m²; Tertile 3: ≥31.6mW/m².