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. 2020 May 1;11:535. doi: 10.3389/fphar.2020.00535

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Copyright © 2020 Liu, Li, Wang, Su, Li, Yan, Ma and Che

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Harmine ameliorates learning and memory impairments in streptozotocin (STZ)–induced diabetic rats. (A) Distances to platform in the different groups on day 1 to day 5 were compared (ANOVA: Day 1: P = 0.535; Day 2: P = 0.18; Day 3: P = 0.005; Day 4: P = 0.005; Day 5: P = 0.031). (B) Latencies for the rats in the different groups to reach the platform on day 1 to day 5 were compared (ANOVA: Day 1: P = 0.127; Day 2: P = 0.133; Day 3: P = 0.034; Day 4: P = 0.041; Day 5: P = 0.034). (C) The number of platform crossings in target quadrant in the probe trial. n = 6 in each group. ^*P < 0.05 vs sham, ^#P < 0.05 vs DM. (D) The percentage of time spent in target quadrant in the probe trial. n = 6 rats in each group. ^*P < 0.05 vs sham, ^#P < 0.05 vs DM. DM, diabetes mellitus; Har, harmine; ND, non-diabetes.