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. 2020 May 1;11:535. doi: 10.3389/fphar.2020.00535

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Copyright © 2020 Liu, Li, Wang, Su, Li, Yan, Ma and Che

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of harmine on brain-derived neurotrophic factor (BDNF)/TrkB in vivo. (A) Harmine increased the level of BDNF in the cortex of streptozotocin (STZ)–induced diabetic rats, as detected by western blotting. Top, western blot images of BDNF. Bottom, related histogram. n = 3 in each group. *P < 0.05 vs sham, ^#P < 0.05 vs DM. (B) Immunohistochemical analysis of BDNF in the hippocampi of diabetic rats after harmine treatment. Lower right panel, quantification of the BDNF-positive area in the brain. (C) Western blot analysis of p-TrkB in the cortex of STZ-induced diabetic rats after harmine treatment. Top, western blot images. Bottom, related histogram. n = 3 in each group. *P < 0.05 vs sham, ^#P < 0.05 vs DM. DM, diabetes mellitus; Har, harmine; p-TrkB, phosphorylated TrkBl; ND, non-diabetes.