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. 2020 May 8;20:208. doi: 10.1186/s12888-020-02636-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — ROC curves for serum IGF-1 level and MDD status. a ROC curve to diagnose MDD in all age groups (18–65 y.o.) (p < 0.0001, AUC: 0.820; sensitivity: 83% and specificity: 71% for a cutoff of 178.00 ng/ml). b ROC curve to diagnose MDD in group 1 (18–24 y.o.) (p = 0.037, AUC: 0.821; sensitivity: 88% and specificity: 71% for a cutoff of 209.50 ng/ml). c ROC curve to diagnose MDD in group 2 (25–34 y.o.) (p < 0.0001, AUC: 0.855; sensitivity: 86% and specificity: 69% for a cutoff of 185.50 ng/ml). d ROC curve to diagnose MDD in group 3 (35–44 y.o.) (p < 0.0001, AUC: 0.975; sensitivity: 84% and specificity: 100% for a cutoff of 178 ng/ml). e ROC curve to diagnose MDD in group 4 (45–54 y.o.) (p = 0.007, AUC: 0.821; sensitivity: 85% and specificity: 75% for a cutoff of 176.00). f ROC curve to diagnose MDD in group 4 (55–65 y.o.) (p = 0.16, AUC: 0.750). AUC: area under the ROC curve; ROC: receiver-operating characteristic.