Table 1:

Baseline demographics of the cohort used in Analysis 1

	Carriers		Noncarriers
	Aware	Unaware	Aware	Unaware
Number	66	57	18	43
Age	43.95 (9.41)	41.25 (7.86)	43 (7.33)	42.19 (8.2)
Education	13.8 (2.75)	13.88 (2.57)	15.22 (3.59)	15.02 (2.62)
Gender (% Female)	52%	65%	61%	53%
CDR greater than zero (%)	71%	25%	0%	5%
APOE Genotype
23	8	3	0	3
24	1	2	0	2
33	35	37	14	25
34	18	13	4	11
44	4	2	0	2
EYO	−0.11 (5.69)	−6.16 (5.59)	−3.82 (6.36)	−4.69 (6.5)
Number of Visits	3.08 (1.33)	2.81 (1.01)	2.72 (1.13)	2.6 (0.93)
Time in Study (years)	2.74 (1.80)	3.33 (1.68)	4.15 (1.88)	3.42 (1.92)
GDS	3.47 (3.33)	2.44 (2.67)	0.83 (1.1)	1.19 (1.5)
CDR Sum	2.82 (3.54)	0.61 (1.51)	0 (0)	0.02 (0.11)
PIB SUVR	2.53 (0.95)	1.82 (0.92)	1.03 (0.07)	1.08 (0.29)
Cognition	−1.42 (1.08)	−0.58 (0.91)	0.13 (0.52)	−0.04 (0.57)
Hippocampal Volume (Adjusted)	0.26 (0.05)	0.3 (0.04)	0.31 (0.03)	0.29 (0.03)

Statistics are reported as mean (SD). Hippocampal volume is reported as a percentage of total intracranial volume.