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. 2020 May 8;19:86. doi: 10.1186/s12944-020-01257-z

fig. 1.

fig. 1

Assumptions of a Mendelian randomization analysis for lifestyle factors and risk of cardiovascular diseases. Broken lines represent potential pleiotropic or direct causal effects between variables that would violate Mendelian randomization assumptions. MVPA = moderate-to-vigorous physical activity, VPA = vigorous physical activity; CAD = coronary artery disease, MI = myocardial infarction