Table 1.

Genome-wide association studies and detailed information of single nucleotide polymorphisms used as instrumental variable in the Mendelian randomization analyses of lifestyle factors in relation to cardiovascular diseases

Traits	SNP	Ethnics	Chr	Position	Nearest gene	EA	EAF	BETA	SE	Sample size	P value	Study	Reference	Journal
Sedentary behaviours	rs26579	Europeans	5	87,985,295	MEF2C-AS2	G	0.415	0.028	0.005	91,105	2.60 × 10− 09	UK Biobank	Aiden Doherty et al.,201828	Nat Commun
Sedentary behaviours	rs25966	Europeans	5	106,822,908	EFNA5	G	0.531	0.028	0.005	91,105	3.00 × 10− 09	UK Biobank	Aiden Doherty et al.,201828	Nat Commun
Sedentary behaviours	rs6801032	Europeans	3	68,527,135	LOC105377146	A	0.259	0.031	0.005	91,105	3.10 × 10−09	UK Biobank	Aiden Doherty et al.,201828	Nat Commun
Sedentary behaviours	rs7779206	Europeans	7	71,723,883	CALN1	A	0.558	0.028	0.005	91,105	4.20 × 10−09	UK Biobank	Aiden Doherty et al.,201828	Nat Commun
MVPA	rs429358	Europeans	19	45,411,941	APOE	T	0.850	−0.019	0.003	377,234	7.30 × 10−11	UK Biobank	Klimentidis YC et al.,201827	Int J Obes (Lond)
MVPA	rs7804463	Europeans	7	133,447,651	EXOC4	T	0.530	0.013	0.002	377,234	4.10 × 10−10	UK Biobank	Klimentidis YC et al.,201827	Int J Obes (Lond)
MVPA	rs2854277	Europeans	6	32,628,084	HLA-DQB1	C	0.920	0.027	0.005	377,234	1.40 × 10−08	UK Biobank	Klimentidis YC et al.,201827	Int J Obes (Lond)
MVPA	rs1379183	Europeans	7	50,237,784	C7orf72/SPATA48	C	0.410	−0.012	0.002	377,234	1.70 × 10−08	UK Biobank	Klimentidis YC et al.,201827	Int J Obes (Lond)
MVPA	rs3094622	Europeans	6	30,327,952	RPP21	A	0.860	0.018	0.003	377,234	1.00 × 10−08	UK Biobank	Klimentidis YC et al.,201827	Int J Obes (Lond)
MVPA	rs149943	Europeans	6	28,002,388	ZNF165	G	0.850	0.016	0.003	377,234	5.60 × 10−08	UK Biobank	Klimentidis YC et al.,201827	Int J Obes (Lond)
MVPA	rs2035562	Europeans	3	85,056,521	CADM2	A	0.330	−0.014	0.002	377,234	1.00 × 10−09	UK Biobank	Klimentidis YC et al.,201827	Int J Obes (Lond)
MVPA	rs7854466	Europeans	9	37,044,388	PAX5	T	0.560	−0.014	0.002	377,234	2.40 × 10−11	UK Biobank	Klimentidis YC et al.,201827	Int J Obes (Lond)
MVPA	rs1043595	Europeans	7	128,410,012	CALU	G	0.720	0.013	0.002	377,234	4.20 × 10−08	UK Biobank	Klimentidis YC et al.,201827	Int J Obes (Lond)
VPA	rs1248860	Europeans	3	85,015,779	CADM2	G	0.480	−0.051	0.007	261,055	5.30 × 10−15	UK Biobank	Klimentidis YC et al.,201827	Int J Obes (Lond)
VPA	rs2764261	Europeans	6	108,927,842	FOXO3	A	0.370	0.030	0.005	261,055	5.30 × 10−08	UK Biobank	Klimentidis YC et al.,201827	Int J Obes (Lond)
VPA	rs13243553	Europeans	7	133,506,955	EXOC4	G	0.610	0.039	0.007	261,055	2.40 × 10−09	UK Biobank	Klimentidis YC et al.,201827	Int J Obes (Lond)
VPA	rs3781411	Europeans	10	126,715,436	CTBP2	C	0.880	0.058	0.009	261,055	1.00 × 10−10	UK Biobank	Klimentidis YC et al.,201827	Int J Obes (Lond)
VPA	rs328902	Europeans	7	35,020,843	DPY19L1	C	0.690	−0.041	0.006	261,055	1.30 × 10−10	UK Biobank	Klimentidis YC et al.,201827	Int J Obes (Lond)
Sleep duration	rs1191685	Europeans	2	113,811,454	PAX8	C	0.370	2.870	0.470	44,563	1.06 × 10−09	CHARGE	Daniel J. Gottlieb et al,201529	Mol Psychiatry
Sleep duration	rs1823125	Europeans	2	113,806,882	PAX8	G	0.260	3.010	0.500	45,281	1.71 × 10−08	CHARGE	Daniel J. Gottlieb et al,201529	Mol Psychiatry
Sleep duration	rs1807282	Europeans	2	113,826,506	PAX8	T	0.260	2.890	0.490	46,805	3.91 × 10−09	CHARGE	Daniel J. Gottlieb et al,201529	Mol Psychiatry
Sleep duration	rs1964463	Europeans	2	113,785,491	PAX8	G	0.250	2.840	0.500	45,281	1.07 × 10−08	CHARGE	Daniel J. Gottlieb et al,201529	Mol Psychiatry
Sleep duration	rs4587207	Europeans	6	30,874,924	IER3	G	0.800	−3.140	0.560	46,807	2.02 × 10−08	CHARGE	Daniel J. Gottlieb et al,201529	Mol Psychiatry
Sleep duration	rs4248149	Europeans	6	30,875,606	IER3	C	0.800	−3.080	0.560	46,810	3.95 × 10−08	CHARGE	Daniel J. Gottlieb et al,201529	Mol Psychiatry
Sleep duration	rs2394403	Europeans	6	30,875,848	IER3	T	0.800	−3.070	0.560	46,811	4.39 × 10−08	CHARGE	Daniel J. Gottlieb et al,201529	Mol Psychiatry

SNP single nucleotide polymorphism; Chr chromosome; EA effect allele; EAF effect allele frequency; SE standard error; MVPA moderate-to-vigorous physical activity; VPA vigorous physical activity; CHARGE the Cohorts for Heart and Aging Research in Genomic Epidemiology