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. 2020 May 8;27:61. doi: 10.1186/s12929-020-00656-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Expression of TGR5 and BRCA1 in the right hemisphere of the rat brain after MCAO. a, b Representative Western blot images and quantitative analyses of TGR5 and BRCA1 time-course expression after MCAO. n = 6 per group. c Double immunofluorescence staining revealed that both TGR5 (red) was predominantly expressed in vWF positive- endothelial cells (green) in penumbra at 24 h after MCAO. n = 4 per group. *P < 0.05 vs sham group. Bars represent mean ± SEM. Scale bar, 50 μm. vWF, Von Willebrand factor. d Whole brain immunofluorescence staining showed that TGR5 expression was upregulated in the cortex, hippocampus and basal ganglia 24 h after MCAO. n = 4 per group. *P < 0.05 vs contralateral non-ischemic hemisphere. Bars represent mean ± SEM. Scale bar, 400 μm